Ability of Mexidol to Enhance Antiexudative Effect of Diclofenac Sodium and Etoricoxib in Rats and Mice with Carrageenan-Induced Edema

Nonsteroidal anti-inflammatory drugs (NSAIDs) are some of the most widely used in existence. However, they can cause numerous side effects. Therefore, it is crucial to develop approaches reducing severity their The purpose this study investigate effect mexidol on activity NSAIDs, such as selective cyclooxygenase (COX)-2 inhibitor etoricoxib and nonselective COX diclofenac sodium. Effect a single oral dose was evaluated rats mice with carrageenan-induced edema by measuring over period 4 6 h, respectively. Diclofenac sodium at doses 1 10 mg/kg exhibits dose-dependent antiexudative effect, these comparable, 25 does not exhibit an effect. In mice, combination noninferior superior mg/kg. rats, significantly reduces h after its induction compared only. more effective than have comparable Mexidol low (25 mg/kg) enhances etoricoxib. decrease NSAIDs will help reduce effects drugs.